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How does an intestinal germ become a pathogen?
Escherichia coli , often abbreviated as E. coli , is part of the human intestinal flora. As a so-called commensal, it does not normally cause any damage there. However, it can become a pathogen in the gut and in other organs. In the urogenital tract, for example, E.…
1.5 million euros for research on human intestinal bacteria
Emerging infectious diseases and antibiotic resistance pose threats to global health. However, commensal microorganisms that colonize the healthy human gut may offer protection against infections. In his project “GUT-CHECK”, Alexander Westermann investigates how the…
Uncovering the HIV life cycle
Key stages in the life cycle of a virus can represent attractive targets for drugs and therapies. Therefore, basic research is important to understand and impact the underlying molecular processes. A distinguishing feature of the HIV-1 variant is that it contains two…
New CRISPR element regulates viral defense
Most bacteria use CRISPR-Cas systems to protect themselves against infecting viruses. The defense systems target snippets of viral DNA and store them between fixed, repeating sequences. These segments, consisting of alternating repeats and snippets of viral DNA, then…
Solidarity with Ukraine
We are following the current events in Ukraine with great concern and dismay. The massive breach of international law committed by the Russian regime under President Vladimir Putin with its invasion on 24 February 2022 cannot be justified by anything. The HZI, like the…
Solidarity with partners in Ukraine – consequences for science and the humanities
The Alliance regards the Russian invasion as an attack on the fundamental values of freedom, democracy and self-determination, which in turn provide the basis for academic freedom and opportunities for academic cooperation. The organisations of the Alliance have long…
A boost for CRISPR research
CRISPR technologies are tools used for genome editing, among other things. Often referred to as "gene scissors", these tools derive from immune systems that protect bacteria from invading viruses. When applied, CRISPR technologies are often based on single proteins such…
Infectious agent offers protection against liver cancer
"Our Listeria -based vaccine delivers tumour-specific antigens while rapidly and efficiently activating an immune response that actively targets the liver tumour. As a result, the activated immune system keeps the growth of the liver tumour under control," explains Dr…
Antiviral and anti-inflammatory
An important task of the human immune system is to maintain the critical balance between efficient defence against a pathogen on the one hand and protection of affected tissues on the other. Disease patterns of viral infections are often characterised by "too much"…
Spin-off project Myxobiotics gains support from new incubator INCATE
First preclinical studies support cystobactamids as rapidly bactericidal, resistance-breaking drugs, which could become a powerful tool in fighting hospital-acquired and ventilator-associated pneumonia and bloodstream infections caused by resistant strains of…
