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Bacteria alter their surface to infect host cells
The flagellums’ long, external filament is composed of several thousand copies of the same protein known as flagellin. The Gram-negative bacteria Salmonella Typhimurium express two distinct flagellins, FliC and FljB, which undergo the methylation of their lysine…
"We are not defenceless against the novel coronavirus"
Professor Heinz, a contact ban has been in effect in Germany since 23 March to slow down the spread of the novel coronavirus SARS-CoV-2. How sensible is this measure in your view? I currently regard the restriction of social contacts as a very important measure to give…
Population study investigates immunity to Covid-19
“Immune individuals could be issued with a kind of vaccination certificate, which would allow them to be exempted from restrictions on their activities, for example,” said Prof Gérard Krause, head of the HZI Department of Epidemiology, to the SPIEGEL. Project partners…
Attractive target for drug against coronavirus
The crystal structure of the enzyme Mpro was identified at a resolution of 1.75 Angstroms. An Angstrom is a unit of length equal to one ten-millionth of a millimetre. Mpro is a key enzyme in the coronavirus’ life cycle as it processes polyproteins that are translated…
Modified tuberculosis vaccine as a therapy for cancer of the bladder
Already at the end of the 19th century, doctors observed that the tumour in some cancer patients shrank if the patients suffered from a bacterial infection with a high fever. These findings sparked interest in immunotherapy for cancer. Immunomodulatory treatments can…
Hope for hepatitis B patients
Prof Carlos A. Guzmán, head of the HZI department “Vaccinology and Applied Microbiology”, together with his team developed the adjuvant c-di-AMP, which is incorporated in the TherVacB vaccine. “We will not only contribute c-di-AMP but also our expertise in order to…
New coronavirus module in SORMAS
Scientists of the Department "Epidemiology" at the HZI lead by Prof Gérard Krause together with German and international partners developed the mobile information system SORMAS. The system operates as an application on mobile phones and is particularly suitable for use…
Expanding the therapeutic use of the antibiotic mupirocin
“Mupirocin is a highly effective antibiotic against methicillin-resistant Staphylococcus aureus (MRSA). However, this drug is rapidly inactivated by proteins in the blood and, therefore, can only be used for local application,” says Prof Eva Medina, head of the research…
Administrative Director Silke Tannapfel leaves the HZI
Silke Tannapfel has been Administrative Managing Director at the Helmholtz Centre for Infection Research (HZI) in Braunschweig since 1 October 2017 and will now leave the Centre at the end of December 2021. She will move to Wiesbaden on 1 January 2022 - with a new job…
Antibodies of vaccinated or hospitalized COVID-19 individuals still recognize the Omicron variant of SARS-CoV-2
The SARS-CoV-2 coronavirus carries different surface proteins, where Spike is the most prominent example and a crucial component of vaccine formulations. The Spike of the new Omicron variant has been investigated by a team of researchers from the Braunschweig University…
