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The gene tinkerer
Since early 2018, the US-American has headed the “RNA Synthetic Biology” research group at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, a location of the HZI in cooperation with the Julius-Maximilians-Universität Würzburg. The chemical…
Keeping antibiotics effective in the future
Dr Castell, what is the focus of WASA? Inappropriate treatment with antibiotics is one of the reasons for the development of antibiotic resistance, which has become a global problem. About 85 per cent of antibiotics are prescribed in ambulatory care – and not always…
World Day for Laboratory Animals on April 24
How do bacteria and viruses trigger diseases? How does our immune system counter them? And what new active substances and vaccines can be used to combat dangerous infections? The scientists at the Helmholtz Centre for Infection Research (HZI) are investigating these and…
World Day for Laboratory Animals and Alternative Models
The use of animal experiments, for example on mice and other rodents, in drug research is necessary to carry out a risk assessment before a potential drug is tested on humans. This also applies, for example, to the development of new antibiotics, where it must also be…
Günter Hansmeier Krebsstiftung funds doctoral thesis at the HZI
The cytomegalovirus (CMV) is a member of the herpes virus family. After the initial infection, which often occurs asymptomatically or with mild, non-specific symptoms in childhood, the virus remains in the body in an inactive stage. Globally, approximately 70 percent of…
Starving pathogens to death
In order to exert their antimicrobial effect, antibiotics specifically intervene in processes that are crucial for the survival or reproduction of bacteria. These include the synthesis of the bacterial cell wall or the duplication of DNA during cell division. Although a…
Crimean-Congo Fever: molecular mechanism of infection discovered
A study led by Josef Penninger, professor at MedUni Vienna and Scientific Director of the Helmholtz Centre for Infection Research (HZI), and Ali Mirazimi from Karolinska Institutet in Stockholm has now decoded the key receptor of the infection, opening up a new avenue…
Bacterial RNAs have shorter lifetimes than expected
Using this new method, the team discovered that the RNA half-life in Salmonella is three times shorter than previously assumed. Additionally, they shed further light on the role of RNA-binding proteins in RNA decay. The results were published in the scientific journal…
New drugs from fungi
In 2021, the Alexander von Humboldt-(AvH) Foundation has started a new initiative to strengthen the research activities in sub-Saharan Africa. The initiative intends to help to deal with the current COVID-19 pandemic and to develop strategies to solve future crises.
Gut microbiota and antibiotics: Missing puzzle piece discovered
The findings, published today in the journal Nature Microbiology , could serve as the foundation for novel therapies addressing intestinal diseases and combating antibiotic resistance. The gut, a complex ecosystem of numerous microorganisms, plays a pivotal role in…
