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Cell protection, immunomodulation and virus inhibition by an endogenous substance
"Itaconic acid has two isomers, natural relatives that differ only slightly in chemical structure, mesaconic and citraconic acid," says PD Dr. Frank Pessler, head of the working group "Biomarkers for Infectious Diseases" at the Institute for Experimental Infection…
The path to personalised hepatitis D treatment
Hepatitis D is caused by coinfection of hepatitis B patients with the hepatitis D virus (HDV). Up to 20 Million individuals are infected with HDV worldwide including about 250.000 patients in the European Union. There is very limited knowledge on disease pathophysiology…
COVID-19: Viral load in lungs supports prognosis in severely ill patients
You studied the viral load in different clinical samples from ventilated COVID-19 patients. What does viral load reveal about the clinical prognosis of patients? For which group of people does this apply? Henrike Maaß: Unfortunately, a clear clinical prognosis is not…
Two bugs with one stone
More and more cases of antibiotic-resistant bacterial pathogens are being reported worldwide. In order to ensure that effective antibiotics will still be available in the future, there is an urgent need to discover antimicrobial compounds with novel structures and…
25 million euros for research transfer
The federal state is providing a budget of 25 million euros for the new biomedical network for the years 2022 to 2026 via the “Niedersächsisches Vorab” initiative of the Volkswagen Foundation. The founding institutions of the IBT are the Hannover Medical School (MHH),…
ScienceHero Award for Melanie Brinkmann
Melanie Brinkmann is a professor at the Institute of Genetics at Technische Universität Braunschweig and heads the research group "Viral Immune Modulation" at the Helmholtz Centre for Infection Research (HZI). Among other things, she has researched the spread of…
Experimenting like the pros: The BioS student laboratory turns 20
“We started with a single course. Today, schools can choose from 21 thematically different courses. We are always fully booked for many months in advance, because at many schools the excursion to the BioS student laboratory is firmly anchored in the curriculum,” recalls…
Sarah Reisman and Christian Hertweck receive Inhoffen Medals
The Inhoffen Medal 2022 was awarded to Prof Sarah Reisman. “For her work, Sarah Reisman always chooses structurally highly complex target molecules of great biological relevance, such as various antibiotics. She is a master of reducing these compounds to much simpler…
New “decision aid” for CRISPR immune responses
Distinguishing self from non-self poses a major challenge for immune systems. Failure to recognize an attacker exposes the host to a potentially fatal infection, while erroneous recognition of the host itself can trigger an autoimmune response. “In order to treat…
A precision cut for the CRISPR-Cas genetic scissors
Bacteria often contain CRISPR-Cas defense systems that protect against viral invaders called phages. In response, phages have evolved proteins that can shut down CRISPR. These are called anti-CRISPR proteins, or Acrs. Researchers believe that there are numerous Acrs…
