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Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target tumours and to colonise them. Researchers are aiming to make use of this property for cancer therapy, but they are facing a dilemma: Salmonella infections are life-threatening. Scientists from the Helmholtz Centre for Infection Research (HZI) in Braunschweig now undertook a successful step towards the clinical application. They developed a Salmonella strain that induces only a harmless infection, but activates the immune system strongly enough to fight the tumours. Their results were published in the journal OncoImmunology.

On 6 October 2017 the "Science Campus Braunschweig-Süd" has been solemnly inaugurated by Lower-Saxony's Minister for Science and Culture, Gabriele Heinen-Kljajić, and Braunschweig's Mayor, Ulrich Markurth. The ceremony was attended by guests from science, industry and politics and has been a highlight in Braunschweig's anniversary year "10 years City of Science" and an important milestone in the development of "Research Region Braunschweig". The future campus partners include the Helmholtz Centre for Infection Research (HZI), the German Center for Infection Research (DZIF), the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, the Technische Universität Braunschweig, the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM and the Biotechnologische Schülerlabor Braunschweig (BioS). The new joint umbrella brand "Science Campus Braunschweig-Süd" is to expand the regional and Germany-wide visibility of the modern Life Science campus, promote the networking of the partnering institutions and attract new cooperation partners and young talent. In addition, with the support of the city of Braunschweig, a new signposting concept has been implemented off-campus.

Microbes may be invisible to the eye, but they are ubiquitous. They are the influential forces behind the regulation of key processes in our environment, for example the carbon cycle. Many microorganisms are not yet known or cannot be maintained in culture. More information about the diversity of species is provided by modern molecular genetic methods, which nowadays allow the entirety of the genome of a habitat – the so-called metagenome – to be investigated. However, the complex analysis of this vast amount of data with a multitude of computer programmes still poses major problems for the researchers. For this reason, scientists of the Helmholtz Centre for Infection Research (HZI) in Braunschweig, the University of Vienna and the University of Bielefeld just started an initiative titled "CAMI – Critical Assessment of Metagenome Interpretation", that tests the tools of metagenome analysis and defines new standards and application options. The researchers published their results in the scientific journal Nature Methods.

Effective 1 October 2017 Silke Tannapfel assumed the responsibilities of the Administrative Director of the Helmholtz Centre for Infection Research (HZI) in Braunschweig. The former head of the Division for Extramural Research Support and Cross-state Bodies in the Bavarian State Ministry for Economy and Media, Energy and Technology based in Munich is the successor to Franziska Broer, who was appointed Executive Manager of the Helmholtz Association in August of last year.

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a pathogen that elicits serious infections in humans and is resistant to a range of antibiotics. Researchers are therefore actively looking for targets for alternative agents that attenuate the bacteria. Pseudomonads can survive in so-called biofilms, which are dense constructs in which the individual bacteria are protected from the immune system and medications. In order to be able to produce a biofilm, the bacteria first have to communicate with each other by means of chemical signals. Scientists from the Helmholtz Centre for Infection Research (HZI) in Braunschweig determined the three-dimensional structure of a protein that is involved in the production of the signaling molecules. Based on this structure, it is now possible to model perfectly fitting inhibitory substances that interrupt the signaling pathway to render the bacteria "mute". The scientists published their results in the international journal ChemBioChem.

The Hannover Medical School (MHH) has seen a great deal of change over the past few years: The school has recently undergone a phase of economic consolidation which also included a change of leadership. Prof Christopher Baum took over the role of President from Prof Dieter Bitter-Suermann four years ago – and inherited a whole host of collaboration projects with the HZI in the process. Christopher Baum spoke to InFact about the developments at the MHH and his plans for expanding the partnership with the HZI.