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Disarming pathogens: New drug candidates to combat chronic infections
Although bacteria are among the simplest life forms on our planet, in the course of evolution they have developed ways to communicate efficiently with each other. Unlike humans, their communication is not mediated with words but with chemical signals. This interaction…
Sugar-based inhibitors disarm the pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative bacterium that belongs to the group of highly antibiotic-resistant and clinically relevant ESKAPE pathogens. According to the World Health Organization (WHO), it is one of the critical priority pathogens because it is often…
DZIF Prize for Translational Infection Research 2022 for epidemiologist Gérard Krause
In his research, Prof Gérard Krause investigates the causes and risk factors for infections as well as the effectiveness of protective measures. One focus is the development of digital instruments and new diagnostic procedures. During the 2014/2015 West African Ebola…
Award-winning dissertation on CRISPR-based diagnostics
Every year, the Helmholtz Association honors the best and most original doctoral theses in each of its six research fields. Since 2022, the Helmholtz Association has been awarding the Doctoral Prize in two different categories in order to recognize doctoral theses with…
Clinical development of two antimicrobial agents funded by Else Kröner-Fresenius Foundation
On the way to clinical application, a potential drug must overcome high and cost-intensive hurdles. To enable individual innovative projects that address an important medical need to carry out the legally required clinical trials, the Else Kröner-Fresenius Foundation's…
New research collaboration on next-generation vaccines against gastrointestinal mucosal pathogens
Against this backdrop, the Technical University of Munich (TUM) coordinates the project Vax2Muc (“Next generation vaccines against gastrointestinal mucosal pathogens, using helicobacter pylori as a model pathogen”), an international and interdisciplinary research…
Charles Thom Award 2023 for Rolf Müller
The award ceremony took place during the Annual SIMB Meeting in Minneapolis, recognizing Prof Müller's exceptional contributions to the scientific community. The Charles Thom Award not only recognizes Müller's remarkable achievements but also emphasizes the importance…
Thomas Pietschmann elected to the Executive Board of the DZIF
At the DZIF General Assembly on 8 November 2023, Prof Thomas Pietschmann was unanimously elected as a new member of the five-person DZIF Executive Board . In addition to his roles at three closely linked DZIF member institutions — the HZI in Braunschweig and the MHH and…
Neutralising antibodies that target resistant bacteria
Antibiotic-resistant bacteria pose a growing threat worldwide, not only to infected patients but also to our health systems as a whole. In particular, infections with the bacterium Pseudomonas aeruginosa are feared due to numerous resistance mechanisms and can lead to…
Pathoblockers to the rescue
Your work describes a new treatment option against Pseudomonas aeruginosa . Why is this bacterium so dangerous and why is there a need for new treatment concepts? J. Haupenthal: "This pathogen plays an a major role in infections of the lungs, wounds and eyes and is…
