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New “decision aid” for CRISPR immune responses
Distinguishing self from non-self poses a major challenge for immune systems. Failure to recognize an attacker exposes the host to a potentially fatal infection, while erroneous recognition of the host itself can trigger an autoimmune response. “In order to treat…
A precision cut for the CRISPR-Cas genetic scissors
Bacteria often contain CRISPR-Cas defense systems that protect against viral invaders called phages. In response, phages have evolved proteins that can shut down CRISPR. These are called anti-CRISPR proteins, or Acrs. Researchers believe that there are numerous Acrs…
On the current situation in Israel
Our thoughts are with all victims and all those taken hostage, and their families and friends. We are shocked and appalled by the atrocious violence that has been perpetrated by the terrorists and strongly condemn these barbaric acts. They cause unspeakable suffering…
26.5 million euros for the construction of the Helmholtz Institute for One Health in Greifswald - Martin announces new state funding
"In Greifswald, a state-of-the-art and world-leading center for infectious disease research will be established in the coming years. If we look at the past years marked by Corona, research into infectious diseases that are transmitted from animals to humans and vice…
IBT Lower Saxony: Lower Saxony's startup incubator for biomedical innovation gets rolling
Two projects each from the Hannover Medical School ( MHH ), the University Medical Center Göttingen ( UMG ) and the Helmholtz Centre for Infection Research (HZI) in Braunschweig presented their promising ideas with prospects for scaling and commercialisation at today's…
Infection model from the 3D printer
To develop new therapeutics against infections, researchers depend on laboratory models that allow them to simulate and study the infection process. Such models are essential, especially in the early testing and development of active substances, in order to keep the…
How the gut microbiome responds to antibiotics
Each person's gut microbiome contains a specific community of microorganisms that normally remains stable for years. However, it can be thrown off balance by factors such as dietary changes, infections or medications. Antibiotics in particular have a strong influence on…
Chemist Jörn Piel receives Inhoffen Medal 2023
The research group of Inhoffen Medal 2023 winner Prof Jörn Piel investigates how structurally complex natural products are produced. “Prof Jörn Piel is an outstanding scientist who has done ground-breaking work on microbial natural products research. His molecular…
A virus lurking in the connective tissue
As part of the new study, Dr Katarzyna Sitnik, then working in the “Viral Immunology” department at the HZI, headed by Prof Luka Cicin-Sain, and her colleagues naturally infected mice with murine CMV (mCMV). This variant of the virus is used because human CMV (HCMV) is…
Small RNA, big impact
How and why do our organs age? To help answer this question, a group of researchers from Saarbrücken and Stanford have been studying some of the molecular mechanisms that underlie ageing. A team led by Andreas Keller, Professor of Clinical Bioinformatics at Saarbrücken…