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Increasingly insensitive to standard drugs: Multi-resistant pathogens are spreading worldwide and even in the near future could threaten the safe treatment of deadly infectious diseases. However, the urgent demand for new antimicrobial agents is offset by a glaring lack of investment into their research. In an article in Nature Reviews Chemistry, the international research alliance IRAADD, which is coordinated by HZI researcher and HIPS director Prof Rolf Müller, presents forward-looking strategies that could be used to solve the problem. Scientists at the German Center for Infection Research (DZIF) are playing a leading role.