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Displaying results 31 to 40 of 234.
Innovative Organoid Research
Organoids are miniature models of human organs cultivated from stem cells in laboratory settings. These delicate tissue structures mimic the three-dimensional architecture and function of real organs, offering researchers a unique opportunity to enhance their understanding of biological processes. Our aim is to advance the development of highly complex organoids incorporating immune cells and vessels. By doing so, we establish a platform, especially for investigating infections, conducting vaccine tests, and innovating therapeutic approaches.
Synthetic biology of microbial natural products
The Bozhüyük group focuses on bacterial natural products, with unique structures and bioactive properties. The group studies modular assembly lines like polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs), which produce many essential clinical agents – but are especially valuable to develop new anti-infectives. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Proteome Analytics
Pathogenic bacteria and viruses utilize and manipulate cellular processes of our immune system. The identification of protein functions in the human immune system that decisively control the progression of infections constitutes the central aim of the research group Cellular Proteomics at the HZI.
Microbial Drugs
The majority of the medically important antibiotic drugs are derived from secondary metabolites, which are produced by bacteria and filamentous fungi. Despite intensive world-wide efforts using alternative approaches, no other concept could so far surpass the historically successful strategy to exploit biologically active natural products as candidates for anti-infective drugs. The recently observed, increasing resistance of the human pathogens against antibiotics has prompted us to intensify our search for novel lead structures from microorganisms and fungi, which can be used as anti-infective drugs.
Laboratory of Transmission Immunology
Transmission of viruses is only possible during a specific time frame after infection: we can call this the “window of transmission”. A major gap in mitigating (e.g., airborne) transmission and closing this window quickly is the lack of understanding of critical immune determinants of efficient transmission. To be able to close the window of transmission through the design of better mitigation strategies, we develop a mechanistic understanding of the spatial and longitudinal interplay between virus tropism, innate and adaptive immune responses, changes in host physiology, and exhalation or shedding of infectious virus in droplets or fluids.
Cellular Proteome Research
Pathogenic bacteria and viruses utilize and manipulate cellular processes of our immune system. The identification of protein functions in the human immune system that decisively control the progression of infections constitutes the central aim of the research group Cellular Proteomics at the HZI.
Research Groups
Research groups Topic overview Bacterial and viral pathogens Immune Response and Interventions Anti-Infectives Technology Platforms Bacterial and viral pathogens The Topic "Bacterial and Viral Pathogens" focuses on the role of pathogenic bacteria and…
Prof Dr Jörg Vogel
Prof Dr Jörg Vogel Head of Research Group +49 931 31 82575 E-Mail Prof. Jörg Vogel is the founding director of the Helmholtz Institute for RNA-based Infection Research (HIRI) as well as the director of the Institute of Molecular Infection Biology (IMIB) at…
Prof Dr Chase Beisel
Prof Dr Chase Beisel Research Group Leader +49 93131-85346 E-Mail Chase Beisel received his bachelors and doctoral degrees in chemical engineering, although he always maintained an interest in engineering biomolecules and biological systems. His doctoral…
Prof Dr Antoine-Emmanuel Saliba
Prof Dr Antoine-Emmanuel Saliba Head of Research Group +49 931 31 81341 E-Mail Antoine-Emmanuel Saliba studied biochemical engineering at INSA Toulouse (France) and received his PhD in the research group of Jean-Louis Viovy at the Institut Curie (Paris,…
