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Molecular Principles of RNA Phages
The research group led by Jens Hör investigates the dynamics of infection, host takeover, and anti-phage defense during the interaction between RNA phages and their hosts. They seek to understand the molecular principles underlying these processes to develop new and improved antibacterial strategies such as phage therapy.
Central Facility for Microscopy
Light microscopy and electron microscopy are excellent high resolution tools to investigate the adhesion and invasion mechanisms of pathogenic bacteria. High resolution electron microscopy permits to examine and unravel pathogenicity mechanisms on a morphological basis. ZEIM offers equipment and highly sophisticated expertise for the preparation and observation of biological samples.
Core Facility of Comparative Medicine
To be able to investigate diseases, understand the relationships between pathogens and their host and to develop novel strategies against pathogens, the scientists at the HZI depend on experiments that involve the use of laboratory animals. For this purpose, the HZI operates a central animal facility on campus. The primary task of this service unit is the breeding and keeping of laboratory mice as well as provision of services for the scientists of the HZI, centered around laboratory animal science.
Transgenic Mice
Genetically modified mice can provide information about the function of particular genes or individual genetic elements. Further, they can be specifically designed to mimic certain physiologic or pathologic conditions. The Service Unit "Transgenic Mice" (TGSM) creates such genetically modified mice for researchers of the center.
Recombinant Protein Expression
Proteins play an important role in infectious diseases. They not only take over central functions in the invasion and replication of pathogens, but also in the defensive reaction of our body or as a drug. For a detailed investigation of proteins, scientists often require them in large amounts and extremely pure state. Read more about how proteins are artificially produced and purified.
Junior Research / Technology / Clinician-Scientist Group Leaders (m/f/d)
The HZI, is offering positions for Junior Research / Technology / Clinician-Scientist Group Leaders (m/f/d) in the field of infection research (with W1-professorship and tenure options).
Proteome Analytics
Pathogenic bacteria and viruses utilize and manipulate cellular processes of our immune system. The identification of protein functions in the human immune system that decisively control the progression of infections constitutes the central aim of the research group Cellular Proteomics at the HZI.
Microbial Drugs
The majority of the medically important antibiotic drugs are derived from secondary metabolites, which are produced by bacteria and filamentous fungi. Despite intensive world-wide efforts using alternative approaches, no other concept could so far surpass the historically successful strategy to exploit biologically active natural products as candidates for anti-infective drugs. The recently observed, increasing resistance of the human pathogens against antibiotics has prompted us to intensify our search for novel lead structures from microorganisms and fungi, which can be used as anti-infective drugs.