Search
Displaying results 71 to 80 of 669.
Genome Architecture and Evolution of RNA Viruses
RNA viruses are a major threat to human health and responsible for millions of deaths each year. Their replication is orchestrated by the RNA genome, which encodes for viral proteins needed to hijack the host cell. Traditionally, infectious disease research has focused on blocking viral replication by inhibiting these proteins. However, we now appreciate that the genomes of RNA viruses are not just passive carriers of protein coding information, but active participants in the viral infection process through the action of non-coding RNA. We study the structure and function of viral non-coding RNA, with the goal of harnessing the resulting knowledge in the design of next generation RNA-based therapies. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI) .
Cellular Proteome Research
Pathogenic bacteria and viruses utilize and manipulate cellular processes of our immune system. The identification of protein functions in the human immune system that decisively control the progression of infections constitutes the central aim of the research group Cellular Proteomics at the HZI.
Human in vitro lung models for testing inhaled drugs
The lung is a highly complex organ made up of over 50 different cell types. In the alveoli, a single layer of cells forms the barrier through which the exchange of oxygen and CO2 between the lungs and the bloodstream takes place. This barrier, also known as the…
A new addition to the CRISPR toolbox: Teaching the gene scissors to detect RNA
Bacteria have developed special defense mechanisms to protect themselves against viruses, which by no means infect only humans. As part of these so-called CRISPR-Cas systems, a CRISPR ribonucleic acid (crRNA), which serves as a “guide RNA,” recognizes regions of a…
Antibiotics of the future?
The collection of myxobacteria at the Helmholtz Centre for Infection Research (HZI) has proven time and again to be a real treasure trove. The soil bacteria, which were initially regarded as not cultivable, have been grown and researched on a large scale since the 1970s…
Dirk Heinz: "The great strengths of the HZI are its solidarity and team spirit"
Professor Heinz, how do you remember the beginning of the pandemic? I remember the last major face-to-face meeting in mid-March 2020 in Berlin very well: a kick-off meeting for the foundation of our new Helmholtz Institute in Greifswald. Even then, everything revolved…
Shining a spotlight on the cellular mechanism
Um die Auswirkungen einer Infektion auf den Zellstoffwechsel sichtbar zu machen, vergleicht er gesunde und infizierte Zellen in Hinblick auf die in ihnen vorhandene RNA (englisch: Ribonucleic Acid). RNA dient in der Zelle als Vorlage für die Herstellung von Proteinen…
New viruses, new challenges
Virus particles are tiny – 20 to 300 nanometres in diameter and thus about 1000 times smaller than a human cell. They consist of little more than their genetic material and a protective protein shell. They even save their own metabolism and use their host’s instead.…
