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Displaying results 651 to 660 of 670.

Persons

Susanne Thiele

Head of Staff Unit, Spokesperson
HZI Campus
Persons

Prof Dr Antoine-Emmanuel Saliba

Head of Research Group
Single-cell Analysis
HIRI
Persons

Myriam Friemelt

Scientist
Innovative Organoid Research
HZI Campus
Persons

Annika Schaperjahn

Technical Assistant
Innovative Organoid Research
HZI Campus
Persons

Anna Festag

Technical Assistant
Innovative Organoid Research
HZI Campus
Persons

Dettmer Regina

Marketing & Event Advertising Assistant
Persons

Claudia Krone-Burges

Research Group

Genome Architecture and Evolution of RNA Viruses

RNA viruses are a major threat to human health and responsible for millions of deaths each year. Their replication is orchestrated by the RNA genome, which encodes for viral proteins needed to hijack the host cell. Traditionally, infectious disease research has focused on blocking viral replication by inhibiting these proteins. However, we now appreciate that the genomes of RNA viruses are not just passive carriers of protein coding information, but active participants in the viral infection process through the action of non-coding RNA. We study the structure and function of viral non-coding RNA, with the goal of harnessing the resulting knowledge in the design of next generation RNA-based therapies. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI) .

Research Group

Single-cell Analysis

Pathogenic bacteria can reside in a mammalian host for a life-long period and chronic carriers form a reservoir leading to recurrent infections. Despite the importance of chronic infections for public health, how a subset of pathogens escape the host’s immune surveillance and how the host contains the spread of bacteria are still poorly understood. Scientists within the Single-Cell Analysis group develop and use single-cell transcriptomics and computational approaches to decipher the microenvironments of individual pathogens and ultimately their functional consequences on infection outcome. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).

Research Group

Virology and Innate Immunity

Pathogens (germs) infiltrate our bodies daily but do not remain undetected. They encounter the strong defenses of our immune system, which recognizes invaders and promptly takes appropriate measures. However, many pathogens can produce life-long infections even with an intact immune system. The herpesvirus family is one such group of pathogens. Upon infection, herpesviruses establish a chronic infection and become lifelong companions.