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Displaying results 641 to 650 of 674.
Epidemiology and ecology of antimicrobial resistance
Due to the interconnectedness between humans, animals and the environment, as well as the rapid potential for antimicrobial resistance to spread between bacterial species, we need a One Health approach to adequately address the threat of antibiotic resistance. This department is based at the Helmholtz Institute for One Health .
Epidemiology
Epidemiology conducts research on health and disease at the population level – infection epidemiology is concerned with contagious diseases. Their tools and methods are systematic queries, clinical examinations and laboratory diagnostic documentation for both healthy and afflicted individuals, as well as statistical analysis of the compiled data. Causes and risk factors for infections can thus be identified. Infectious diseases epidemiology contributes to the development of preventive measures, early detection and therapy for diseases. Moreover, it examines the efficacy of such measures. Thus epidemiology ties in with scientific findings in basic research as well as medicine, and examines these processes at the population level.
Antiviral Antibody-Omics
Antibodies are key components of the adaptive immune system and are critical for defending against infectious diseases. In our research group, we strive to gain a better understanding of the mechanisms of antibody-mediated protection, with the ultimate objective of creating novel and more effective vaccine and treatment strategies for infectious diseases. The junior research group is based at TWINCORE in Hannover.
Anti-infectives from Microbiota
The department of Prof Christine Beemelmanns focuses on the identification and functional analysis of novel anti-infective natural products from microbial communities. Co-cultivation studies as well as cell-based assays in combination with chemical-analytical and molecular-biological methods are used to evaluate and prioritize novel natural product producers. The department uses established and innovative metabolomic-, activity and genome-based methods to identify and determine the structure of the secreted natural products. Based on the isolated novel natural substances, the functional analysis and evaluation of their range of effects is carried out. This department is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Chemical Biology
In their ongoing quest for new therapies against pathogens, scientists are focusing primarily on chemical agents. Discovering new bioactive compounds, characterising their functionality and optimising their properties are the three main goals of the Department of Chemical Biology (CBIO) at the HZI.
Biostatistics
High-Throughput-technologies generate large amounts of data. The drawback: these biological and medical data must be processed to results with statistical methods and models. Concepts from robust and computational statistics as well as visualisation techniques help to better understand, estimate and cope with the uncertainty and strong variation that are often inherent in biological and medical data. The project group „Biostatistics“ is part of the research group „Cellular Proteome Research” which is led by Lothar Jänsch.
Biomarkers of Infectious Diseases
The Research Group Biomarkers of Infectious Diseases aims to identify more accurate diagnostic, prognostic and predictive host biomarkers for infectious diseases and the vaccine response. The clinical aims of the group are to help select the most effective, individualized treatment as early as possible, aiming to streamline the use of anti-infectives (improve anti-infective stewardship) and to improve clinical outcome. This group is located at the TWINCORE in Hannover.
Biological Barriers and Drug Delivery
While considering the confusing flood of drugs in the pharmacies it is hard to believe in a lack of medication. But there are still many infectious diseases and also cancer that cannot be treated sufficiently. During a medical treatment it is essential that the drug arrives at the envisaged body region. Read more about the research of the department “Biological Barriers and Drug Delivery” on techniques for the correct distribution of novel drugs. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Chemical Biology of Carbohydrates
Carbohydrates and glycoconjugates belong to the three major classes of biopolymers. Complex carbohydrates play important roles in biological recognition processes that are represented by the presence of dense glycoconjugate layers on cells known as the glycocalyx. Despite their importance, the study of carbohydrates suffers from limited methods for their synthesis and analysis contrary to nucleic acids or proteins. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS).
Antiviral and Antivirulence Drugs
Work in the Empting lab focuses on tackling innovative and difficult-to-address anti-infective targets such as bacterial virulence regulatory systems as well as un(der)explored anti-herpesviral persitance mediators. By this, we aspire to circumvent common resistance mechanisms and to refill the dried out development pipeline. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
