Search
Displaying results 101 to 110 of 231.
Third-Party Funds Acquisition
Third-Party Funds Acquisition With more than 20 years of experience and expertise as multipliers and service providers, the members of the staff unit Third-Party Funds Acquisition (DA) advise and support the scientific staff of the HZI, the DSMZ (German…
Administration and Infrastructure
Administration and Infrastructure The administrative units and staff units of the administration and infrastructure support the scientific work at the HZI. Approximately 200 people are employed in the administration of the HZI across all locations (as of…
Safety and environmental protection
Safety and Environmental Affairs The department for safety and environmental affairs takes over the central duties for occupational health and safety (OHS) and environmental affairs that should not be delegated to the heads of the departments of the…
Scientific strategy
Scientific Strategy The Staff Unit Scientific Strategy (WST) supports the management and the scientific steering committee in developing and implementing the centre's strategy. WST coordinates the preparation of scientific-strategic concepts and…
Strategic Communication
Strategic Communication The strategy departments work on behalf of the management and in close cooperation with colleagues from research and administration. The main goal is to make concepts for the scientific development of the HZI. The Task of the…
Integrative Informatics for Infection Biology
Recent years have seen accelerating development of high-throughput technologies in infection biology. Now, thousands of genetic loci can be simultaneously interrogated in a single experiment, providing an array of measurements of transcription, translation, regulatory interactions, and fitness effects. The bottleneck in advancing our understanding of pathogens now lies in moving from hypothesis-free screening through data integration to hypothesis generation. We develop new statistical, computational, and visualization approaches to overcome this bottleneck in the interpretation of complex post-genomic data. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
Genome Architecture and Evolution of RNA Viruses
RNA viruses are a major threat to human health and responsible for millions of deaths each year. Their replication is orchestrated by the RNA genome, which encodes for viral proteins needed to hijack the host cell. Traditionally, infectious disease research has focused on blocking viral replication by inhibiting these proteins. However, we now appreciate that the genomes of RNA viruses are not just passive carriers of protein coding information, but active participants in the viral infection process through the action of non-coding RNA. We study the structure and function of viral non-coding RNA, with the goal of harnessing the resulting knowledge in the design of next generation RNA-based therapies. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI) .
Microbial Proteomics
A genome contains all the information that is needed to build an organism like, for instance, a bacterium. One of functional genomics’ central questions is: How are these blueprints implemented so that relatively simple molecular codes ultimately give rise to a microorganism with the potential of getting us sick? What are some of the underlying mechanisms and under what conditions do they become activated?
Microbial Natural Products
Even today efficient drugs against many diseases are missing but finding new active substances is very complex. Support comes out of the ground. Myxobacteria are soil-living microorganisms that produce many active agents. Here you learn more about the search for new compounds with biological activity. This department is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Microbial Interactions and Processes
Microorganisms in the environment are living in complex and interacting communities. Also the surfaces of the human body are inhabited by microorganisms, where the bacterial cell number significantly exceeds that of the human cells. These communities have co-evolved with the human host and are important for human health. They can, however, also be a reservoir for pathogenic microorganisms.
