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Ebola
Ebola © Adobe Stock/jaddingt The outbreaks are sudden and severe. The Ebola fever then spreads rapidly throughout the Endemic disease area. The rate of fatality often is higher than 50%, sometimes up to 90%. Currently, there is no specific antidote and no…
Biofilms
Biofilms – living in slime Covered by a thick slimy coating made of biopolymers, the bacteria shield themselves from the immune system and antibiotics. In Germany alone, some 100,000 infections annually are related to biofilms – with clinically relevant…
Information for pupils
Information for Pupils Biotechnological School Lab Braunschweig (BioS) © HZI/Christine Bentz Pupils in the Biotechnological School Lab Braunschweig (BioS) The Biotechnological School Lab Braunschweig has been open to pupils in grades 11 to 13 since spring…
Imprint
Imprint according to the following German regulations: § 6 TDG, § 10 MDStV Publisher Helmholtz-Zentrum für Infektionsforschung GmbH (Helmholtz Centre for Infection Research) Inhoffenstraße 7 38124 Braunschweig Telefon: 0531 6181-0 Telefax: 0531 6181-2655…
Host-Pathogen-Microbiota Interactions
The importance of RNA in maintaining cellular physiology by controlling gene expression in response to intrinsic and external cues has long been underestimated. Now, numerous human diseases have been linked to RNA functioning. Likewise, we now know that bacterial pathogens harness a large suite of noncoding RNA molecules to adapt to environmental stress and to precisely regulate their virulence programs. In an era of antibiotic crisis, it is essential to discover alternative combat strategies against pathogenic bacteria — ideally ones that spare the beneficial microbial species. The high specificity of RNA molecules provides great potential for achieving these goals. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
RNA Synthetic Biology
RNA is a ubiquitous molecule of life that plays intimate roles in how cells function and make decisions. These same properties can be harnessed to create a new generation of engineering tools to further interrogate the properties of biology and control how cells behave. The “RNA synthetic biology” group aims to better understand the roles RNA plays in biology and to exploit these roles to improve how we study, diagnose, and treat infectious diseases in humans. This department is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
RNA Biology of bacterial infections
The Vogel lab strives to chart the diversity of noncoding RNA functions and RNA-binding proteins in major bacterial pathogens and in the hundreds of different bacteria that make up the human microbiome. We develop new RNA deep sequencing-based techniques to capture the RNA world of any microbe, ideally at the single cell level. We want to understand how and why bacteria use RNA as a regulator during infection and exploit this knowledge to target pathogens and edit the microbiota with precision. Projects focus on several bacteria from our major workhorse Salmonella Typhimurium to anaerobic microbes that are associated with colorectal cancer such as Fusobacterium nucleatum . This Department is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
Personalised Immunotherapy
Our motivation is to address fundamental questions of human immunology and translate them into personalized therapies and diagnostics. Specifically, our laboratory discovers new applications of antibodies and B cells to treat and prevent human infectious diseases. Effective vaccines against some viruses that escape antibody responses remain elusive. To tackle this challenge, we develop methods to better understand B cell responses, the cells that produce antibodies. We design tailored vaccines and provide novel solutions for infection diagnostics. This Department is located at the Centre for Individualised Infection Medicine ( CiiM ).
Nano Infection Biology
Viruses are nanoscale entities. Despite their size and low complexity, they efficiently enter host cells leading to infection and reprogramming of cellular functions. The critical processes involve only a handful of viral and cellular proteins. Yet this contact is critical for the outcome of infection and the cellular immune response. We look at these processes to understand which cellular processes are stimulated by viruses and how the host cell interprets an infecting virus at the molecular level. At the scale of single viruses, these processes, their dynamics and structural conditions remain mostly unclear. We thus use advanced microscopy techniques, which allow us to visualize viral and cellular nanostructures during the infection process.
